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Conformational Flexibility of a Synthetic Glycosylaminoglycan Bound to a Fibroblast Growth Factor. FGF-1 Recognizes Both the 1C4 and 2SO Conformations of a Bioactive Heparin-like Hexasaccharide

AuthorsCanales, Ángeles CSIC ORCID; Angulo, Jesús CSIC ORCID; Ojeda, Rafael; Bruix, M. CSIC ORCID; Fayos, Rosa CSIC; Lozano, R.M. CSIC ORCID ; Giménez-Gallego, Guillermo CSIC; Martín-Lomas, Manuel; Nieto, Pedro M. CSIC ORCID ; Jiménez-Barbero, Jesús CSIC ORCID
Iduronic acid
Issue Date2-Apr-2005
PublisherAmerican Chemical Society
CitationJournal of the American Chemical Society 127(16): 5778-5779 (2005)
AbstractThe first direct NMR determination of the conformation of a conformationally flexible heparin-like hexasaccharide bound to a key receptor, FGF-1, is described. The determination has been based on the use of a 13C-labeled protein and a regular 12C sugar. FGF-1 recognizes several conformations of the iduronic moieties of the hexasaccharide. Therefore, this case is different than that described for the controversial recognition of heparin-like saccharides by AT-III, which seems to recognize just one conformation of the iduronic acid residues.
Description2 páginas, 1 figura, 1 tabla, esquemas.
Publisher version (URL)http://dx.doi.org/10.1021/ja043363y
Appears in Collections:(IIQ) Artículos
(ICMM) Artículos
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