English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/37254
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

Molecular diversity of voltage-gated sodium channel α and β subunit mRNAs in human tissues

AuthorsCandenas, M. Luz CSIC ORCID; Seda, Marian; Noheda Marín, Pedro CSIC ORCID ; Buschmann, Helmut; Cintado, Cristina G.; Martín, Julio D.; Pinto Pérez, Francisco M. CSIC ORCID
KeywordsVoltage-gated Na+ channel
α subunit
β subunit
mRNA expression
Peripheral tissue
Human
Issue Date3-May-2006
PublisherElsevier
CitationEuropean Journal of Pharmacology 541(1-2): 9-16 (2006)
AbstractVoltage-gated Na+ channels are composed of one α subunit and one or more auxiliary β subunits. A reverse transcription–polymerase chain reaction assay was used to analyse the expression of the nine known α subunits (Nav1.1–Nav1.9) in 20 different human tissues. The mRNA expression of the currently known β subunits (β1, β2, β3 and β4) was also assessed. The mRNAs of voltage-gated Na+ channel α and β subunits were found in a wide variety of human tissues assayed and were present in neuronal and non-neuronal types of cells. These data suggest that, in addition to its well-established role in skeletal muscle, cardiac cells and neurons, voltage-gated Na+ channels might play important, still undetermined local roles in the regulation of cellular functions. These channels could emerge in the next future as potential, new therapeutic targets in the treatment of visceral diseases.
Description8 páginas, 4 figuras, 2 tablas.
Publisher version (URL)http://dx.doi.org/10.1016/j.ejphar.2006.04.025
URI10261/37254
DOIhttp://dx.doi.org/10.1016/j.ejphar.2006.04.025
ISSN0014-2999
Appears in Collections:(IQOG) Artículos
(IIQ) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.