Synthesis and Biological Evaluation of a Heparin-Like Hexasaccharide with the Structural Motifs for Binding to FGF and FGFR

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Título:	Synthesis and Biological Evaluation of a Heparin-Like Hexasaccharide with the Structural Motifs for Binding to FGF and FGFR
Autor:	Paz, José L. de CSIC ORCID; Martín-Lomas, Manuel CSIC
Palabras clave:	Growth factor activation Heparin Synthesis design Oligosaccharides Carbohydrates
Fecha de publicación:	25-abr-2005
Editor:	Wiley-VCH
Citación:	European Journal of Organic Chemistry (9): 1849-1858 (2005)
Resumen:	A heparin-like hexasaccharide structure (2) containing the two trisaccharide sequences that interact with acidic fibroblast growth factor (FGF-1) and with its receptor (FGFR) has been designed on the basis of crystallographic data. This hexasaccharide has been effectively synthesized by a completely stereoselective modular approach and biologically evaluated by determination of its capacity to stimulate FGF-1-induced mitogenic activity. It was found that this molecule did not show an appreciable FGF-1 activating effect.
Descripción:	10 páginas, 3 figuras, 1 tabla, 3 esquemas.
Versión del editor:	http://dx.doi.org/10.1002/ejoc.200400799
URI:	http://hdl.handle.net/10261/37241
DOI:	10.1002/ejoc.200400799
ISSN:	1434-193X
E-ISSN:	1099-0690
Aparece en las colecciones:	(IIQ) Artículos

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