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dc.contributor.authorChevalier, Franck-
dc.contributor.authorLópez-Prados, Javier-
dc.contributor.authorPérez, Serge-
dc.contributor.authorMartín-Lomas, Manuel-
dc.contributor.authorNieto, Pedro M.-
dc.date.accessioned2011-06-28T11:06:24Z-
dc.date.available2011-06-28T11:06:24Z-
dc.date.issued2005-07-01-
dc.identifier.citationEuropean Journal of Organic Chemistry (16): 3489-3498 (2005)es_ES
dc.identifier.issn1434-193X-
dc.identifier.urihttp://hdl.handle.net/10261/37238-
dc.description10 páginas, 4 figuras, 2 tablas, esquemas.es_ES
dc.description.abstractThe solution three-dimensional structure of pseudopentasaccharide 6, which constitutes the product from the GPI-PLD cleavage of a GPI anchor, has been studied using a protocol which involves a systematic search of the conformational space around the glycosidic linkages, a thorough molecular dynamics study with explicit water molecules and a full NMR analysis study of intramolecular hydrogen bonding in solution. The results indicate that 6 exists in an extended conformation with a considerable flexibility compatible with a hinge-like conformational motion.es_ES
dc.description.sponsorshipWe thank Prof. Lennart Kenne and Dr. Corine Sandström for their precious help with hydroxy detection technique, Alain Rivet for his support in molecular modelling, and D. Anne Milet for Gaussian access at the LEDSS (http://www-chimie.ujf-grenoble.fr/LEDSS/RESUM/resum.html) and the CECIC at the Institut de Chimie Moléculaire, Grenoble. We would like to thank the European Union for a predoctoral fellowship (TMR programme: Grant HRN-CT-2000-00001/GLYCOTRAIN).es_ES
dc.language.isoenges_ES
dc.publisherWiley-VCHes_ES
dc.rightsclosedAccesses_ES
dc.subjectGPI anchores_ES
dc.subjectConformational analysises_ES
dc.subjectMolecular flexibilityes_ES
dc.subjectMolecular modellinges_ES
dc.subjectNMR spectroscopyes_ES
dc.titleConformational Study of GPI Anchors: the Common Oligosaccharide GPI Anchor Backbonees_ES
dc.typeArtículoes_ES
dc.identifier.doi10.1002/ejoc.200500171-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1002/ejoc.200500171es_ES
dc.identifier.e-issn1099-0690-
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