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Title

Conformational Study of GPI Anchors: the Common Oligosaccharide GPI Anchor Backbone

AuthorsChevalier, Franck; López-Prados, Javier; Pérez, Serge; Martín-Lomas, Manuel; Nieto, Pedro M.
KeywordsGPI anchor
Conformational analysis
Molecular flexibility
Molecular modelling
NMR spectroscopy
Issue Date1-Jul-2005
PublisherWiley-VCH
CitationEuropean Journal of Organic Chemistry (16): 3489-3498 (2005)
AbstractThe solution three-dimensional structure of pseudopentasaccharide 6, which constitutes the product from the GPI-PLD cleavage of a GPI anchor, has been studied using a protocol which involves a systematic search of the conformational space around the glycosidic linkages, a thorough molecular dynamics study with explicit water molecules and a full NMR analysis study of intramolecular hydrogen bonding in solution. The results indicate that 6 exists in an extended conformation with a considerable flexibility compatible with a hinge-like conformational motion.
Description10 páginas, 4 figuras, 2 tablas, esquemas.
Publisher version (URL)http://dx.doi.org/10.1002/ejoc.200500171
URIhttp://hdl.handle.net/10261/37238
DOI10.1002/ejoc.200500171
ISSN1434-193X
E-ISSN1099-0690
Appears in Collections:(IIQ) Artículos
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