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NMR Investigation of the Bound Conformation of Natural and Synthetic Oligomannosides to Banana Lectin

AuthorsClavel, Caroline; Canales, Ángeles ; Gupta, Garima; Cañada, F. Javier ; Penadés, Soledad; Surolia, Avadhesha; Jiménez-Barbero, Jesús
KeywordsMannose oligosaccharides
NMR spectroscopy
Molecular dynamics
Banana lectin
Molecular recognition
Issue Date9-Feb-2007
CitationEuropean Journal of Organic Chemistry (10): 1577-1585 (2007)
AbstractThe conformational behaviour of three mannose-containing oligosaccharides, namely, the α1→3[α1→6] trisaccharide, a heptasaccharide with α1→2, α1→3 and α1→6 linkages and a tetrasaccharide consisting of α1→3 and α1→2 linkages, when bound to banana lectin (BanLec) has been evaluated by trNOE NMR methods and docking calculations. It was found that the molecular recognition event involves a conformational selection process with only one of the conformations present in the free state of the sugar being recognised at the lectin binding site.
Description9 páginas, 7 figuras, 3 tablas.
Publisher version (URL)http://dx.doi.org/10.1002/ejoc.200600897
Appears in Collections:(CIB) Artículos
(IIQ) Artículos
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