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Título: | Entacapone potentiates the long-duration response but does not normalize levodopa-induced molecular changes |
Autor: | Marín, Concepció; Aguilar, Esther; Mengod Los Arcos, Guadalupe CSIC ORCID; Cortés, Roser CSIC ORCID; Rodríguez-Oroz, M. Cruz; Obeso, José Ángel | Palabras clave: | Parkinson's disease Levodopa Entacapone 6-Hydroxydopamine Preproenkephalin Preprodynorphin |
Fecha de publicación: | dic-2008 | Editor: | Elsevier | Citación: | Neurobiology of Disease | Resumen: | Coadministration of entacapone with levodopa attenuates motor complications in experimental models of Parkinson's disease. The mechanisms underlying entacapone effects are unknown. We investigated the effect of entacapone, on: long-duration response (LDR) to levodopa, levodopa-induced postsynaptic pharmacodynamic mechanisms and molecular changes in hemiparkinsonian rats. 6-Hydroxydopamine-unilaterally lesioned rats were treated with levodopa (25 mg/kg) + vehicle; levodopa + entacapone (30 mg/kg) or saline, twice daily for 22 days. The LDR and the apomorphine-induced rotations were measured. In situ hybridization was performed measuring the expression of striatal preproenkephalin, preprodynorphin and dopamine D-3 receptor mRNAs, subthalamic cytochrome oxidase mRNA and nigral glutamic acid decarboxylase mRNA. Entacapone potentiated the LDR but did not modify either the apomorphine-induced rotational behavior or the molecular changes. Our results suggest that the effects of entacapone on levodopa-induced motor response are not mediated by postsynaptic mechanisms and that administration of entacapone is not able to normalize the molecular alterations induced by levodopa in the basal ganglia. | Descripción: | El pdf del artículo es el manuscrito de autor. | Versión del editor: | http://dx.doi.org/10.1016/j.nbd.2008.07.019 | URI: | http://hdl.handle.net/10261/37163 | DOI: | 10.1016/j.nbd.2008.07.019 | ISSN: | 0969-9961 | E-ISSN: | 1095-953X |
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Entacapone potentiates.pdf | 627,14 kB | Adobe PDF | Visualizar/Abrir |
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