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Title: | Role for interleukin 4 in the differentiation of mature T cell receptor [gamma/delta]+ cells from human intrathymic T cell precursors |
Authors: | Bárcena, Alicia; Toribio, María Luisa CSIC ORCID; Pezzi, Luis; Martínez-Alonso, Carlos | Issue Date: | Aug-1990 | Publisher: | Rockefeller University Press | Citation: | The Journal of Experimental Medicine, Volume 172, August 1990, pp. 439-446 | Abstract: | We have analyzed the effect of human recombinant interleukin 4 (rIL4) on the growth and differentiation of human intrathymic pre-T cells (CD7+2+1-3-4-8-) . We describe that this population of T cell precursors proliferates in response to rIL4 (in the absence of mitogens or other stimulatory signals) in a dose-dependent way. The IL-4-induced proliferation is independent of the IL-2 pathway, as it cannot be inhibited with an anti-IL2 receptor a chain antibody. In our culture conditions, rIL4 also promotes the differentiation of preT cells into phenotypically mature T cells. Although both CD3/T cell receptor (TCR)-[alfa/beta]+ and CD3-[gamma/delta]+ T cells were obtained,the preferential differentiation into TCR-y/a+ cells was a consistent finding. These results suggest that, in addition to IL-2, IL4 plays a critical role in promoting growth and differentiation of intrathymic T cell precursors at early stages of T cell development | Description: | El copyright pertenece a The Rockefeller University Press | URI: | http://hdl.handle.net/10261/3692 | ISSN: | 0022-1007 |
Appears in Collections: | (CNB) Artículos |
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