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dc.contributor.authorCortés, María José-
dc.contributor.authorDíez-Juan, Antonio-
dc.contributor.authorPérez, Paloma-
dc.contributor.authorPérez-Roger, Ignacio-
dc.contributor.authorArroyo-Pellicer, Rosa-
dc.contributor.authorAndrés, Vicente-
dc.date.accessioned2011-06-15T12:19:22Z-
dc.date.available2011-06-15T12:19:22Z-
dc.date.issued2002-07-
dc.identifier.citationFebs Letters 52281): 99-103 (2002)es_ES
dc.identifier.issn0014-5793-
dc.identifier.urihttp://hdl.handle.net/10261/36850-
dc.description5 páginas, 5 figuras.-- El documento en word es la versión post-print.es_ES
dc.description.abstractWe sought to determine the relative importance of aging and hypercholesterolemia on atherosclerosis. Although plasma cholesterol levels increased similarly in young and old rabbits fed an atherogenic diet for 2 months, aortic atherosclerotic lesions were more prominent in young animals. This finding was associated with an age-dependent reduction in the DNA-binding activity of the proinflammatory nuclear factor κB (NF-κB) in aortic tissue. Atherosclerotic lesions consisted mostly of macrophages, which displayed a similar proliferative response in both age groups. Independently of the age, medial cell proliferation was low and increased as a function of intimal lesion size. Thus, higher atherogenicity in young rabbits exposed to extreme hypercholesterolemia compared to old counterparts is associated with higher activity of NF-κB in the juvenile vessel wall without apparent age-dependent changes in arterial cell proliferation.es_ES
dc.description.sponsorshipThis work was supported by grants from the Spanish Government and Fondo Europeo de Desarrollo Regional (PM97- 0136, SAF2001-2358) and from the American Heart Association, Massachusetts Affiliate (9860022T). A.D.-J. was partially supported by the Spanish Government and Fondo Europeo de Desarrollo Regional (Grant 1FD97-1035-C02-02), and by Fondo Social Europeo (CSIC-Programa I3P fellowship). M.J.C. was supported by a CSICBancaja postdoctoral fellowship.es_ES
dc.language.isoenges_ES
dc.publisherFederation of American Societies for Experimental Biologyes_ES
dc.publisherElsevieres_ES
dc.rightsopenAccesses_ES
dc.subjectAtherosclerosises_ES
dc.subjectAginges_ES
dc.subjectHypercholesterolemiaes_ES
dc.subjectProliferationes_ES
dc.titleIncreased early atherogenesis in young versus old hypercholesterolemic rabbits by a mechanism independent of arterial cell proliferationes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/S0014-5793(02)02902-2-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/S0014-5793(02)02902-2es_ES
dc.identifier.pmid12095626-
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