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Título: | Increased early atherogenesis in young versus old hypercholesterolemic rabbits by a mechanism independent of arterial cell proliferation |
Autor: | Cortés, María José CSIC; Díez-Juan, Antonio CSIC ORCID; Pérez, Paloma CSIC ORCID ; Pérez-Roger, Ignacio; Arroyo-Pellicer, Rosa; Andrés, Vicente CSIC ORCID | Palabras clave: | Atherosclerosis Aging Hypercholesterolemia Proliferation |
Fecha de publicación: | jul-2002 | Editor: | Federation of American Societies for Experimental Biology Elsevier |
Citación: | Febs Letters 52281): 99-103 (2002) | Resumen: | We sought to determine the relative importance of aging and hypercholesterolemia on atherosclerosis. Although plasma cholesterol levels increased similarly in young and old rabbits fed an atherogenic diet for 2 months, aortic atherosclerotic lesions were more prominent in young animals. This finding was associated with an age-dependent reduction in the DNA-binding activity of the proinflammatory nuclear factor κB (NF-κB) in aortic tissue. Atherosclerotic lesions consisted mostly of macrophages, which displayed a similar proliferative response in both age groups. Independently of the age, medial cell proliferation was low and increased as a function of intimal lesion size. Thus, higher atherogenicity in young rabbits exposed to extreme hypercholesterolemia compared to old counterparts is associated with higher activity of NF-κB in the juvenile vessel wall without apparent age-dependent changes in arterial cell proliferation. | Descripción: | 5 páginas, 5 figuras.-- El documento en word es la versión post-print. | Versión del editor: | http://dx.doi.org/10.1016/S0014-5793(02)02902-2 | URI: | http://hdl.handle.net/10261/36850 | DOI: | 10.1016/S0014-5793(02)02902-2 | ISSN: | 0014-5793 |
Aparece en las colecciones: | (IBV) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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FEBS Lett. 522 99-103 (2002).doc | 16,61 MB | Microsoft Word | Visualizar/Abrir |
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