Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/3677
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Immune networks : frequencies of antibody and idiotype producing B cell clones in various steady states |
Autor: | Bernabé, Rosa R.; Coutinho, Antonio; Martínez-Alonso, Carlos; Cazenave, Pierre-André | Fecha de publicación: | ago-1981 | Editor: | Rockefeller University Press | Citación: | The Journal of Experimental Medicine, Volume 154, August 1981, pp. 552-556 | Resumen: | The network theory of the immune system can be reduced to the interactions between soluble and cell-bound idiotypes and combining sites, independently of the functional properties of the lymphocytes bearing those elements . After its original exposition, however, much attention has been drawn to the functionally opposing consequences of the activity mediated by distinct classes of lymphocytes. The "plusminus" general network interactions have thus been progressively substituted by "mini-networks" of suppressor and helper T cells, often disconnected from the overall regulatory influences maintaining steady states in a complete, and therefore circular, repertoire . It appeared important, therefore, to establish a primary, quantitative description of the immune elements in various steady states to provide the basis for a description of immune networks . This, on the other hand, would perhaps contribute to resolving the present problems of predicting pathways in network interactions and the consequences of specific manipulations . We have initiated these attempts by determining B cell precursor frequencies in quantitative assays , under conditions that limit only for the clonal precursor itself. This was done in a well-characterized system prototype of network regulation using monoclonal idiotypes and anti-idiotypes | Descripción: | El copyright pertenece a The Rockefeller University Press | URI: | http://hdl.handle.net/10261/3677 | ISSN: | 0022-1007 |
Aparece en las colecciones: | (CNB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
23.pdf | 277,29 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
365
checked on 18-abr-2024
Download(s)
203
checked on 18-abr-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.