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Title

Molecular Basis for β-Glucosidase Inhibition by Ring-Modified Calystegine Analogues

AuthorsAguilar Moncayo, Matilde ; Gloster, Tracey M.; García Moreno, María Isabel; Ortiz-Mellet, Carmen; Davies, Gideon J.; Llebaria, Amadeu; Casas, Josefina; Egido-Gabás, Meritxell; García-Fernández, José Manuel
KeywordsAzasugars
Calystegines
Glucosidases
Iminosugars
Inhibitors
Issue Date2-Oct-2008
PublisherWiley-VCH
CitationChemBioChem 9(16): 2612-2618 (2008)
AbstractNeutral calystegine B2analogues, such as the 1-deoxy-6-oxa-N-(N′-octyl)thiocarbamoyl derivative, proved to be more potent β-glucosidase inhibitors than the natural alkaloid. Structural studies of the complex with a clan GH-A β-glucosidase from Thermotoga maritima showed a binding mode markedly different from that of the parent compound.
Description7 páginas, 3 figuras, 2 tablas, 3 esquemas
Publisher version (URL)http://dx.doi.org/10.1002/cbic.200800451
URIhttp://hdl.handle.net/10261/36618
DOI10.1002/cbic.200800451
ISSN1429-4227
E-ISSN1439-7633
Appears in Collections:(IIQ) Artículos
(IQAC) Artículos
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