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Título: | 6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin: Synthesis, Biological Evaluation, and Crystal Structure in Complex with Acid β-Glucosidase |
Autor: | Brumshtein, Boris; Aguilar Moncayo, Matilde; García Moreno, María Isabel; Ortiz-Mellet, Carmen; García Fernández, José Manuel CSIC ORCID; Silman, Israel; Shaaltiel, Yoseph; Aviezer, David; Sussman, Joel L.; Futerman, Anthony H. | Palabras clave: | Acid beta-glucosidase Gaucher disease Guanidine Iminosugars Inhibitors Nojirimycin |
Fecha de publicación: | 13-may-2009 | Editor: | Wiley-VCH | Citación: | ChemBioChem 10(9): 1480-1485 (2009) | Resumen: | 6-Amino-6-deoxy-5,6-di-N-(N′-octyliminomethylidene)nojirimycin, a reducing analogue of N-nonyl-1-deoxynojirimycin, proved to be a potent and very selective inhibitor of β-glucosidases, including human acid β-glucosidase. Structural studies of the enzyme–inhibitor complex showed a binding mode in which the anomeric hydroxy group is accommodated in the “wrong” α configuration. | Descripción: | 6 páginas, 4 figuras, 2 tablas, 1 esquema | Versión del editor: | http://dx.doi.org/10.1002/cbic.200900142 | URI: | 10261/36616 | DOI: | 10.1002/cbic.200900142 | ISSN: | 1429-4227 | E-ISSN: | 1439-7633 |
Aparece en las colecciones: | (IIQ) Artículos |
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