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TSAO Derivatives: Highly Specific Inhibitors of Human Immunodeficiency Virus Type-1 (HIV-1) Replication

AuthorsCamarasa Rius, María José ; Peréz-Pérez, María-Jesús ; Velázquez, Sonsoles ; San-Félix, Ana ; Álvarez, Rosa; Jimeno, M. Luisa
Issue Date1995
PublisherTaylor & Francis
CitationNucleosides, Nucleotides and Nucleic Acids 14 (3 & 5) : 585 - 594 (1995)
AbstractTSAO derivatives represent a unique class of nucleosides that are specifically targeted at HIV-1 RT. This overview is focussed on the chemical synthesis, the conformational studies, the antiviral and metabolic properties of TSAO derivatives, as well as their mechanism of antiviral action and the molecular basis of the rapid selection of resistant HIV-1 strains that emerge in cell culture in the presence of TSAO derivatives.
Publisher version (URL)http://dx.doi.org/10.1080/15257779508012432
Appears in Collections:(CENQUIOR) Artículos
(IQM) Artículos
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