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Title

Synthesis of N-, S-, and C-glycoside castanospermine analogues with selective neutral α-glucosidase inhibitory activity as antitumour agents

AuthorsSánchez-Fernández, Elena M. ; Rísquez-Cuadro, Rocio; Chasseraud, Maud; Ahidouch, Ahmed; Ortiz-Mellet, Carmen; Ouadid-Ahidouch, Halima; García-Fernández, José Manuel
Keywordssp2-Iminosugar-type
Inhibitor
α-glucosidases
N-glycoprotein processing
Breast cancer
Antiproleferative
Pseudoanomeric
Issue Date15-Jun-2010
PublisherRoyal Society of Chemistry (UK)
CitationChemical Communications 46(29): 5328-5330 (2010)
Abstractsp2-Iminosugar-type castanospermine analogues bearing an α-configured N-, S-, or C-linked pseudoanomeric group have been designed as selective inhibitors of the neutral α-glucosidases involved in N-glycoprotein processing; evaluation in breast cancer cell growth indicated a significant antiproliferative potential that was dependent on the nature of the pseudoanomeric group.
Description3 páginas, 2 figuras, 1 tabla, 1 esquema
Publisher version (URL)http://dx.doi.org/10.1039/C0CC00446D
URIhttp://hdl.handle.net/10261/36290
DOI10.1039/C0CC00446D
ISSN1359-7345
Appears in Collections:(IIQ) Artículos
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