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Título : Polarization of chemokine receptors to the leading edge during lymphocyte chemotaxis
Autor : Nieto, Marta; Frade, José M.R.; Sancho, David; Mellado, Mario; Martínez-Alonso, Carlos; Sánchez Madrid, Francisco
Fecha de publicación : jul-1997
Editor: Rockefeller University Press
Citación : The Journal of Experimental Medicine, Volume 186, Number 1, July 7, 1997, pp. 153–158
Resumen: Leukocyte migration in response to cell attractant gradients or chemotaxis is a key phenomenon both in cell movement and in the inflammatory response. Chemokines are quite likely to be the key molecules directing migration of leukocytes that involve cell polarization with generation of specialized cell compartments. The precise mechanism of leukocyte chemoattraction is not known, however. In this study, we demonstrate that the CC chemokine receptors CCR2 and CCR5, but not cytokine receptors such as interleukin (IL)-2R a ,IL-2R b, tumor necrosis factor receptor 1, or transforming growth factor b R, are redistributed to a pole in T cells that are migrating in response to chemokines. Immunofluorescence and confocal microscopy studies show that the chemokine receptors concentrate at the leading edge of the cell on the flattened cell-substratum contact area, induced specifically by the signals that trigger cell polarization. The redistribution of chemokine receptors is blocked by pertussis toxin and is dependent on cell adhesion through integrin receptors, which mediate cell migration. Chemokine receptor expression on the leading edge of migrating polarized lymphocytes appears to act as a sensor mechanism for the directed migration of leukocytes through a chemoattractant gradient.
Descripción : El copyright pertenece a The Rockefeller University Press
URI : http://hdl.handle.net/10261/3626
ISSN: 0022-1007
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