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Title

Modulating glycosidase degradation and lectin recognition of gold glyconanoparticles

AuthorsBarrientos, Africa G.; Martínez de la Fuente, Jesús; Jiménez, Marta; Solís, D. ; Cañada, F. Javier ; Martín-Lomas, Manuel; Penadés, Soledad
KeywordsGold glyconanoparticles
Glycosidases
Lectins
Multivalent presentation
Molecular recognition
Issue Date17-Aug-2009
PublisherElsevier
CitationCarbohydrate Research 344(12): 1474-1478 (2009)
AbstractGlyconanoparticles (GNPs) are water-soluble carbohydrate-functionalized gold nanoclusters with a promising potential to serve as versatile tools in studies ranging from basic chemical glycobiology to clinical applications. In this paper we evaluate the influence of ligand density and presentation on the recognition by protein receptors by examining the interaction of lactose-functionalized GNPs with two different galactose-specific carbohydrate-binding proteins: an enzyme, Escherichia coli β-galactosidase, and a lectin, Viscum album agglutinin. The results suggest that the proper selection of ligand densities and spacers in GNP functionalization is an important requisite to match the topological requirements of the target receptor while escaping glycosidase degradation.
Description5 páginas, 3 figuras, 1 tabla
Publisher version (URL)http://dx.doi.org/10.1016/j.carres.2009.04.029
URIhttp://hdl.handle.net/10261/36189
DOI10.1016/j.carres.2009.04.029
ISSN0008-6215
Appears in Collections:(IIQ) Artículos
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