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dc.contributor.authorPennefather, Jocelyn N.-
dc.contributor.authorPatak, Eva-
dc.contributor.authorZiccone, Sebastian-
dc.contributor.authorLilley, Alison-
dc.contributor.authorPinto Pérez, Francisco M.-
dc.contributor.authorPage, Nigel M.-
dc.contributor.authorStory, Margot E.-
dc.contributor.authorGrover, Sonia-
dc.contributor.authorCandenas, M. Luz-
dc.identifier.citationBiology of Reproduction 75(3): 334-341 (2006)es_ES
dc.description8 páginas, 7 figuras, 1 tablaes_ES
dc.description.abstractRegulation of the contractile effects of tachykinins and histamine on the human uterus was investigated with biopsy sections of the outer myometrial layer. The effects of neurokinin A (NKA) and human hemokinin-1 (hHK-1) in tissues from pregnant but not from nonpregnant women were enhanced by the inhibition of neprilysin. The effects of NKA and eledoisin were blocked by the NK2 receptor antagonist SR 48968 but not by the NK1 receptor antagonist SR 140333 in tissues from both groups of women. Human HK-1 acted as a partial agonist blocked by SR 48968 and, to a lesser extent, by SR 140333; endokinin D was inactive. In tissues from pregnant women, responses to high potassium-containing Krebs solution were 2–3-fold higher than those from nonpregnant women. Mepyramine-sensitive maximal responses to histamine were similarly enhanced. The absolute maximum responses to NKA and its stable NK2 receptor-selective analogue, [Lys5MeLeu9Nle10]NKA(4–10), were increased in pregnancy, but their efficacies relative to potassium responses were decreased. Tachykinin potencies were lower in tissues from pregnant women than in those from nonpregnant women. These data 1) show for the first time that hHK-1 is a uterine stimulant in the human, 2) confirm that the NK2 receptor is predominant in mediating tachykinin actions on the human myometrium, and 3) indicate that mammalian tachykinin effects are tightly regulated during pregnancy in a manner that would negate an inappropriate uterotonic effect. The potencies of these peptides in tissues from nonpregnant women undergoing hysterectomy are consistent with their possible role in menstrual and menopausal disorders.es_ES
dc.description.sponsorshipSupported by grants from the National Health and Medical Research Council of Australia to J.N.P. and the Ministerio de Educación y Ciencia (BFU2005-04495-C02-01/BFI), Spain.es_ES
dc.publisherSociety for the Study of Reproductiones_ES
dc.subjectFemale reproductive tractes_ES
dc.subjectHuman myometriumes_ES
dc.subjectNeurokinin Aes_ES
dc.subjectSignal transductiones_ES
dc.subjectUterine contractionses_ES
dc.titleRegulation of the Stimulant Actions of Neurokinin A and Human Hemokinin-1 on the Human Uterus: A Comparison with Histaminees_ES
dc.description.peerreviewedPeer reviewedes_ES
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