Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/36125
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Simón-Areces, Julia | - |
dc.contributor.author | Membrive, Gema | - |
dc.contributor.author | García Fernández, Carmen | - |
dc.contributor.author | García-Segura, Luis M. | - |
dc.contributor.author | Arévalo, María Ángeles | - |
dc.date.accessioned | 2011-05-26T14:34:46Z | - |
dc.date.available | 2011-05-26T14:34:46Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | The Journal of Comparative Neurology 518 (10):1814–1824 (2010) | - |
dc.identifier.issn | 0021-9967 | - |
dc.identifier.uri | http://hdl.handle.net/10261/36125 | - |
dc.description | 11 pages, 3 figures. - PMID: 20235092 [PubMed - indexed for MEDLINE] | es_ES |
dc.description.abstract | Neurogenin 3 (Ngn3), a proneural gene controlled by the Notch receptor, is implicated in the control of dendrite morphology and synaptic plasticity of cultured hippocampal neurons. Here we report the localization and subcellular distribution of Ngn3 in the hippocampus in vivo and in neuronal cultures. In situ hybridization showed Ngn3 mRNA expression in the pyramidal layer and dentate gyrus of adult mouse hippocampus. Immunohistochemistry studies revealed that Ngn3 localization is mostly cytoplasmic in the hippocampal eminence at embryonic day (E)17 and postnatal day (P)0. At P10 it is cytoplasmic in CA1–CA3 pyramidal neurons and nuclear in granule cells of the dentate gyrus. In the adult hippocampus Ngn3 is localized in the nucleus and cytoplasm of both pyramidal neurons and granule cells. During development of cultured hippocampal neurons, Ngn3 mRNA expression is higher at stages of neuronal polarization, as judged by reverse-transcription polymerase chain reaction (RT-PCR), and it is mostly cytoplasmic. The tracking of the subcellular localization of Ngn3 in neurons infected with a virus expressing myc-Ngn3 suggests that the protein is quickly translocated to the cell nucleus after synthesis and then reexported to the cytoplasm. Treatment with leptomycinB, a potent and specific inhibitor of the exportin CRM1, induced its accumulation into the nucleus, suggesting that CRM1 mediates the nuclear export of Ngn3. These results suggest that Ngn3 may play a role in neuronal development by actions in the cytoplasm. | es_ES |
dc.description.sponsorship | Fundación La Caixa. Grant Number: 2005X1045 Spanish Ministerio de Ciencia e Innovación. Grant Number: BFU 2008-02950-C03-01 Comunidad de Madrid. Grant Number: CCG08-CSIC/SAL-3617 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | - |
dc.rights | closedAccess | es_ES |
dc.subject | proneural gene | es_ES |
dc.subject | neuron development | es_ES |
dc.subject | pyramidal layer | es_ES |
dc.subject | dentate gyrus | es_ES |
dc.title | Neurogenin 3 cellular and subcellular localization in the developing and adult hippocampus | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/cne.22304 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://onlinelibrary.wiley.com/doi/10.1002/cne.22304/abstract | es_ES |
dc.identifier.e-issn | 1550-7130 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IC) Artículos |
CORE Recommender
SCOPUSTM
Citations
26
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
24
checked on 26-feb-2024
Page view(s)
330
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.