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Título: | ABCA1 polymorphisms and Alzheimer´s disease |
Autor: | Wavrant-De Vrièze, Fabienne; Compton, Danielle; Womick, Meridith; Arepalli, Sampath; Adighibe, Omanma; Li, Ling; Pérez-Tur, Jordi CSIC ORCID ; Hardy, John | Palabras clave: | ABCA1 Alzheimer’s disease Polymorphisms |
Fecha de publicación: | 7-feb-2007 | Editor: | Elsevier | Citación: | Neuroscience Letters 416(2): 180–183 (2007) | Resumen: | In our search for genetic factors related to the development of Alzheimer’s disease, we have genotyped 332 pedigrees for 3 coding polymorphisms in the ABCA1 gene, two of which are known to alter plasma cholesterol levels, as well as a non-coding polymorphism within the promoter. We show an apparent weak association of rs2230806 (p-value= 0.01) with the disease in a sibpair series of Alzheimer’s disease that had shown previously evidence for linkage to the chromosome 9 locus where ABCA1 maps. | Descripción: | Final full-text version of the paper available at: http://ees.elsevier.com/nsl/. Copyright © by Elsevier. | URI: | http://hdl.handle.net/10261/3583 | DOI: | 10.1016/j.neulet.2007.02.010 | ISSN: | 0304-3940 |
Aparece en las colecciones: | (IBV) Artículos |
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