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Sphingosine Increases the Permeability of Model and Cell Membranes

AutorContreras, F. Xabier; Sot, Jesús; Alonso, Alicia; Goñi, Félix M.
Fecha de publicación1-jun-2006
EditorBiophysical Society
CitaciónBiophys J. 2006 June 1; 90(11): 4085–4092
ResumenSphingosine, at 5–15 mol % total lipids, remarkably increases the permeability to aqueous solutes of liposomal and erythrocyte ghostmembranes. The increased permeability cannot be interpreted in terms of leakage occurring at the early stages of a putative membrane solubilization by sphingosine, nor is it due to a sphingosine-induced generation of nonlamellar structures, or flipflop lipid movement. Instead, sphingosine stabilizes (rigidifies) gel domains in membranes, raising their melting temperatures and increasing the transition cooperativity. Structural defects originating during the lateral phase separation of the ‘‘more rigid’’ and ‘‘less rigid’’ domains are likely sites for the leakage of aqueous solutes to the extravesicularmedium. The presence of coexisting domains in the plasma membrane makes it a target for sphingosine permeabilization. The sphingosine-induced increase in rigidity and breakdown of the plasma membrane permeability barrier could be responsible for some of the physiological effects of sphingosine.
DescripciónCopyright © by Biophysical Society. Final full-text version of the paper available at: http://www.biophysj.org/cgi/content/abstract/90/11/4085
URIhttp://hdl.handle.net/10261/3537
DOI10.1529/biophysj.105.076471
ISSN1542-0086
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