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Title

A new and efficient one-pot synthesis of pyrido[2,1-f]purine-2,4-diones starting from 6-aminouracil derivatives

AuthorsPérez Pérez, María Jesús; Priego, Eva María ; Jimeno, M. Luisa ; Camarasa Rius, María José
Keywordsheterocycles
tricyclic compounds
pyridines
halogenation
N-bromosuccinimide
Issue Date2002
PublisherThieme
CitationSynlet 1 : 155-157 (2002)
AbstractA convenient synthesis of pyrido[2,1-f]purine-2,4-diones is described by reaction of 6-aminouracil derivatives with N-bromosuccinimide (NBS) followed by in situ reaction with pyridine or 4-substituted pyridines. A detailed study of the reaction conditions has been performed and a mechanism involving a 5,5-dibromo derivative is proposed.
Publisher version (URL)http://dx.doi.org/10.1055/s-2002-19342
URIhttp://hdl.handle.net/10261/35271
DOI10.1055/s-2002-19342
ISSN0936-5214
Appears in Collections:(CENQUIOR) Artículos
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