Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/35213
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Harms and benefits of lymphocyte subpopulations in patients with acute stroke

AuthorsUrra, Xabier; Cervera, Álvaro; Planas, Anna M. CSIC ORCID; Chamorro, Ángel
KeywordsStroke
Lymphocytes
Stroke-associated infection
Outcome
Issue Date6-Feb-2009
PublisherElsevier
CitationNeuroscience 158(3): 1174-1183 (2009)
AbstractLymphocytes are major players in the development of innate and adaptive immune responses but their behavior in patients with acute stroke has received little attention.
[Experimental procedures]: Using flow cytometry we identified total lymphocytes, T cells, helper T (Th) cells, cytotoxic T lymphocytes (CTL), natural killer (NK) cells, B cells, and regulatory T (Treg) cells in 46 consecutive patients with acute stroke within a median of 180 min of clinical onset, and at days 2, 7, and 90. Daily neurological score (National Institutes of Health Stroke Scale), diffusion-weighted imaging on brain magnetic resonance imaging, functional impairment, and stroke-associated infection (SAI) at day 7 were assessed. Apoptosis in lymphocyte subsets, tumor necrosis factor (TNF) -α/interleukin (IL) -4 production in stimulated Th and CTL, cluster of differentiation 86 (CD86) (B7-2) expression in B cells, cortisol and metanephrine in serum were measured. Multivariate analyses were used to evaluate SAI, and stroke outcome.
[Results]: Increased apoptosis and a fall of T, Th, CTL, B, and Treg cells were observed after stroke. Severer stroke on admission and SAI disclosed a greater decline of T, Th, and CTL cells. Increased cortisol and metanephrine was associated with severe stroke and SAI, and inversely correlated with T, and CTL. T cells, and CTL were correlated with infarct growth. Stroke but not SAI resulted in lower TNF-α production in Th cells. SAI showed the greatest fall of lymphocytes, T, Th, and CTL, but not B cells, or Treg. Poor outcome was associated with reduced levels of B cells, and increased expression of CD86 in B cells, but not with SAI.
[Conclusion]: Lymphopenia and increased apoptosis of T, Th, CTL, Treg and B cells are early signatures after human stroke. A decreased cellular response after stroke is a marker of ongoing brain damage, the stress response, and a higher risk of infection. A lower humoral response is predictor of poorer long-term outcome.
Publisher version (URL)http://dx.doi.org/10.1016/j.neuroscience.2008.06.014
URIhttp://hdl.handle.net/10261/35213
DOI10.1016/j.neuroscience.2008.06.014
ISSN0306-4522
E-ISSN1873-7544
Appears in Collections:(IIBB) Artículos

Files in This Item:
File Description SizeFormat
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

SCOPUSTM   
Citations

153
checked on May 11, 2022

WEB OF SCIENCETM
Citations

144
checked on May 14, 2022

Page view(s)

408
checked on May 18, 2022

Download(s)

121
checked on May 18, 2022

Google ScholarTM

Check

Altmetric

Dimensions


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.