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Título : The IclR family of transcriptional activators and repressors can be defined by a single profile
Autor : Krell, Tino; Molina Henares, Antonio Jesús; Ramos, Juan L.
Palabras clave : IclR
Transcriptional regulator
Family profile
Fecha de publicación : may-2006
Editor: Cold Spring Harbor Laboratory. Press
Citación : Protein Science 15(5): 1207–1213 (2006)
Resumen: In the last decade enormous advances in life sciences have been possible due to the information obtained from DNA sequencing projects. The optimal interpretation and analysis of genome sequence data requires the precise annotation and classification of proteins deduced from open reading frames, which is usually done with the help of family-specific signatures. Here we report a novel profile for the IclR type of transcriptional activators and repressors. In contrast to profiles for other families of transcriptional regulators, the new IclR profile is located outside the helix-turn-helix DNA-binding motif. We provide evidence that the new profile is more specific than any of the existing signatures for this family of regulators. More than 500 representatives of this family were identified with this profile. A database on bacterial regulators (http://www.bactregulators.org) was built to compile and regroup the sequences with the aid of the new profile.
Descripción : Article and publication date are at http://www.proteinscience.org/cgi/doi/10.1110/ps.051857206
Versión del editor: http://dx.doi.org/10.1110/ps.051857206
URI : http://hdl.handle.net/10261/3521
DOI: 10.1110/ps.051857206
ISSN: 1469-896X
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