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Title

The IclR family of transcriptional activators and repressors can be defined by a single profile

AuthorsKrell, Tino; Molina Henares, Antonio Jesús; Ramos, Juan L.
KeywordsIclR
Transcriptional regulator
Family profile
Issue DateMay-2006
PublisherCold Spring Harbor Laboratory Press
CitationProtein Science 15(5): 1207–1213 (2006)
AbstractIn the last decade enormous advances in life sciences have been possible due to the information obtained from DNA sequencing projects. The optimal interpretation and analysis of genome sequence data requires the precise annotation and classification of proteins deduced from open reading frames, which is usually done with the help of family-specific signatures. Here we report a novel profile for the IclR type of transcriptional activators and repressors. In contrast to profiles for other families of transcriptional regulators, the new IclR profile is located outside the helix-turn-helix DNA-binding motif. We provide evidence that the new profile is more specific than any of the existing signatures for this family of regulators. More than 500 representatives of this family were identified with this profile. A database on bacterial regulators (http://www.bactregulators.org) was built to compile and regroup the sequences with the aid of the new profile.
DescriptionArticle and publication date are at http://www.proteinscience.org/cgi/doi/10.1110/ps.051857206
Publisher version (URL)http://dx.doi.org/10.1110/ps.051857206
URIhttp://hdl.handle.net/10261/3521
DOI10.1110/ps.051857206
ISSN1469-896X
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