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Título:	Brain mitochondrial alterations after chronic alcohol consumption
Autor:	Fernández, Anna; García-Ruiz, Carmen CSIC ORCID ; Fernández-Checa, José C. CSIC ORCID; Romero, F. J.
Palabras clave:	Alcohol Mitochondria Brain Glutathione Cholesterol Rat Apoptosis
Fecha de publicación:	sep-2009
Editor:	Springer Nature
Citación:	Journal of Physiology and Biochemistry 65(3): 305-312 (2009)
Resumen:	The aim of this study was to demonstrate the existence of alterations in glutathione and cholesterol homeostasis in brain mitochondria from alcoholic rats. Glutathione concentration decreased, whereas oxidized glutathione and cholesterol contents increased in these organelles, suggesting the ethanol-induced generation of reactive oxygen species, and the impairment of mitochondrial uptake of glutathione, possibly due to the increase in cholesterol deposition. The release of apoptogenic proteins was increased after stimulating mitochondria from the brain of alcoholic rats with atractyloside. As a conclusion, chronic alcohol consumption might sensitize brain mitochondria to apoptotic stimuli, and promote the subsequent release of apoptotic proteins.
Descripción:	et al.
Versión del editor:	http://dx.doi.org/10.1007/BF03180583
URI:	http://hdl.handle.net/10261/35177
DOI:	10.1007/BF03180583
ISSN:	1138-7548
E-ISSN:	1877-8755
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Brain mitochondrial alterations after chronic alcohol consumption