English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/34874
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorBonache, María-Cruz-
dc.contributor.authorChamorro, Cristina-
dc.contributor.authorCordeiro, Alessandra-
dc.contributor.authorCamarasa Rius, María José-
dc.contributor.authorJimeno, M. Luisa-
dc.contributor.authorSan-Félix, Ana-
dc.identifier.citationJournal of Organic Chemistry 69 : 8758-8766 (2004)es_ES
dc.description.abstractWe report here the efficient regio-and stereoselective synthesis of new polycyclic nucleosides using a common cyclic enamine (7) as the starting material. In fact, the reaction of 7, easily prepared by reaction of 5¢-O-Tosyl TSAO-T under basic nonnucleophilic conditions (potassium carbonate), with different classes of nucleophiles, for example, nitrogen-, oxygen-, sulfur-, and carbon-based nucleophiles, or with amino acids afforded, with total regio-and stereoselectivity, new bi-, tri-, and tetracyclic nucleosides. This straighforward route represents an original and unambiguously regio- and stereoselective pathway to these compounds. Some of these polycyclic nucleosides may be useful intermediates for a second series of reactions that may lead to the generation of structurally new nucleosides.es_ES
dc.description.sponsorshipWe thank Susana Ruiz and Marı´a Jose´ Galeote for their excellent technical as- sistance. We thank the Ministry of Education of Spain for grants to C.C. and M.-C.B. The Spanish Ministerio de Ciencia y Tecnologı´a (Project SAF2003-07219-C02- 01) and the European Commission (Projects QLK2-CT- 2000-00291 and HPAW-CT-2002-90001) are acknowl- edged for their financial support.es_ES
dc.publisherAmerican Chemical Societyes_ES
dc.titleSynthesis of novel Bi-, Tri-, and tetracyclic nucleosides by reaction of a common cyclic enamine derived from TSAO-T with nucleophileses_ES
dc.description.peerreviewedPeer reviewedes_ES
Appears in Collections:(CENQUIOR) Artículos
Files in This Item:
There are no files associated with this item.
Show simple item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.