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Analysis, accumulation and central effects of trihalomethanes. I. bromoform

AuthorsParra, P. ; Martínez, Emili ; Suñol, Cristina ; Tusell, Josep Maria ; Gelpí, Emili ; Artigas, Francesc
Central nervous system
Potable water
Issue Date1988
PublisherTaylor & Francis
CitationToxicological and Environmental Chemistry 11 (2) : 79-91 (1988)
AbstractThe paper presents the results obtained in a study on the effects of organic micropollutants on the central nervous system of the rat, used herein as a suitable model for neurotoxicologic work. Bromoform, a member of the trihalomethane (THM) family, was the pollutant selected since it becomes a characteristic marker in the Barcelona potable water supply. Analytical data on the GC-ECD separation of THMs from other volatile halocarbons is presented. A mixed packed column 10% SE-30/PEG 20M (94:6) at 70°C provides an adequate separation. The distribution of bromoform in rat plasma and tissues showed an accumulation in brain, kidney and fat, increasing in this order and a rapid elimination after 30 min. The effect on the central aminergic metabolism is studied by HPLC. The increased metabolic activity detected could be attributed either to an increased nervous activity, stimulating the metabolism of serotonin, or to its greater degradation.
Publisher version (URL)http://dx.doi.org/10.1080/02772248609357122
Appears in Collections:(IIBB) Artículos
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