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dc.contributor.authorCamón, LLuïsa-
dc.contributor.authorMartínez, Emili-
dc.contributor.authorArtigas, Francesc-
dc.contributor.authorSolà, Carme-
dc.contributor.authorRodríguez-Farré, Eduard-
dc.date.accessioned2011-04-20T09:20:03Z-
dc.date.available2011-04-20T09:20:03Z-
dc.date.issued1988-05-
dc.identifier.citationToxicology - Kidlington 49 (2-3) : 389-394 (1988)es_ES
dc.identifier.issn0300-483X-
dc.identifier.urihttp://hdl.handle.net/10261/34832-
dc.description.abstractThe effect of lindane (γ-HCH) on temperature, food intake and body weight was studied in male and female rats after single or repeated non-convulsant oral doses. A single dose of 30 mg/kg induced a significant decrease of core temperature (0.4°C in males and 0.66°C in females) 5 h after administration when compared to the control value. Lindane-induced hypothermia was strongly potentiated (1.45°C) by cold stress when rats were kept at 4°C. The same dose of lindane produced a significant decrease in body weight gain (−85% in males and −219% in females compared to the control gain), accompanied by a diminution of food intake, 24 h after administration. No decrease in both parameters was observed when α- or δ-HCH isomers 30 mg/kg were tested. After daily administration with 10 mg/kg lindane for 7 days, no hypothermic effects were observed. However, a slight but significant decrease in body weight gain was recorded over the treatment period. This effect was also accompanied by a reduced food intake. The observed stereoselective effects of HCH isomers on core temperature and body weight could be a useful model to study the mechanisms of lindane neurotoxicity at low subconvulsant doses.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectLindanees_ES
dc.subjectHexachlorocyclohexane isomerses_ES
dc.subjectCore temperaturees_ES
dc.subjectBody weightes_ES
dc.subjectFood intakees_ES
dc.titleThe effect of non-convulsant doses of lindane on temperature and body weightes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/0300-483X(88)90023-6-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/0300-483X(88)90023-6es_ES
dc.identifier.e-issn1879-3185-
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