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The effect of non-convulsant doses of lindane on temperature and body weight

AuthorsCamón, LLuïsa ; Martínez, Emili ; Artigas, Francesc ; Solà, Carme ; Rodríguez-Farré, Eduard
Hexachlorocyclohexane isomers
Core temperature
Body weight
Food intake
Issue DateMay-1988
CitationToxicology - Kidlington 49 (2-3) : 389-394 (1988)
AbstractThe effect of lindane (γ-HCH) on temperature, food intake and body weight was studied in male and female rats after single or repeated non-convulsant oral doses. A single dose of 30 mg/kg induced a significant decrease of core temperature (0.4°C in males and 0.66°C in females) 5 h after administration when compared to the control value. Lindane-induced hypothermia was strongly potentiated (1.45°C) by cold stress when rats were kept at 4°C. The same dose of lindane produced a significant decrease in body weight gain (−85% in males and −219% in females compared to the control gain), accompanied by a diminution of food intake, 24 h after administration. No decrease in both parameters was observed when α- or δ-HCH isomers 30 mg/kg were tested. After daily administration with 10 mg/kg lindane for 7 days, no hypothermic effects were observed. However, a slight but significant decrease in body weight gain was recorded over the treatment period. This effect was also accompanied by a reduced food intake. The observed stereoselective effects of HCH isomers on core temperature and body weight could be a useful model to study the mechanisms of lindane neurotoxicity at low subconvulsant doses.
Publisher version (URL)http://dx.doi.org/10.1016/0300-483X(88)90023-6
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