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Title

Comparative ontogenesis of brain tryptamine, serotonin and tryptophan

AuthorsArtigas, Francesc CSIC ORCID; Suñol, Cristina CSIC ORCID; Tusell, Josep Maria CSIC; Martínez, Emili CSIC ORCID; Gelpí, Emili CSIC
KeywordsOntogenesis
Tryptophan
Tryptamine
Serotonin
HPLC
Mass fragmentography
Issue DateJan-1985
PublisherJohn Wiley & Sons
CitationJournal of Neurochemistry 44 (1) : 31-37 (1985)
AbstractThe pattern of ontogenetic development of tryptophan (TP), tryptamine (T), indole-3-acetic acid (IAA), 5-hydroxytryptamine (5-HT; serotonin), and 5-hydroxyindole-3-acetic acid (5-HIAA) in the brains of rats aged 1–45 days is presented. Analysis of the five components in each brain allows the calculation of the acid/amine and amine/amino acid ratios. These metabolic indexes are a useful tool to study and compare the metabolic origins and fates of both amines. The ontogenetic patterns of TP, T, and IAA are very similar, especially during the first week postpartum. The highest and lowest levels found for T were 2.2 ng/g and 0.1 ng/g at the 1st and 5th day, respectively. The temporal relationship between the T/TP and IAA/T ratios suggests the existence of mechanisms protecting T against monoamine oxidase (MAO) which develop in parallel to synaptogenesis. Significant correlations were found between TP and IAA during the whole period studied and between TP and T during the first week after birth. The 5-HT peak found during the first postpartum week could be due to a non-neuronal pool of 5-HT protected against MAO and possibly contained in mast cells. Preliminary determinations on leptomeningeal membranes suggest the existence of such a pool.
Publisher version (URL)http://dx.doi.org/10.1111/j.1471-4159.1985.tb07108.x
URIhttp://hdl.handle.net/10261/34830
DOI10.1111/j.1471-4159.1985.tb07108.x
ISSN0022-3042
E-ISSN1471-4159
Appears in Collections:(IIBB) Artículos

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