Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/34807
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Title

Changes in polyamine levels in rat brain after systemic kainic acid administration: relationship to convulsant activity and brain damage

AuthorsVera, Núria de CSIC ORCID ; Artigas, Francesc CSIC ORCID; Serratosa, Joan CSIC ORCID CVN; Martínez, Emili CSIC ORCID
KeywordsPutrescine
Spermidine
Spermine
Kainic acid
Brain damage
Convulsions
Issue DateJul-1991
PublisherJohn Wiley & Sons
CitationJournal of Neurochemistry 57 (1 ): 1-8 (1991)
AbstractWe have examined the effects of systemic kainic acid (KA) administration (9 mg/kg, i.p.) on rat behavior, brain damage, and polyamine levels and the action of the specific ornithine decarboxylase inhibitor α-difluoromethylornithine (DFMO) on these effects. KA elicited convulsant activity in 63% of the animals. In the acute convulsant phase (1–3 h after KA), a rapid decline (−39% at 3 h) of spermidine content in frontal cortex was found. After the acute convulsant phase, levels of hippocampal spermidine and spermine were reduced (−70 and −66%, respectively, at 8 h). A dramatic increase of putrescine content (681, 1,382, and 336% at 8h, 24h, and 9 days, respectively, after KA) was found, associated with histological signs of cortical brain damage (ischemia and necrosis). There was a close relationship between the concentration of putrescine and signs of delayed toxicity (body weight losses) 24 h and 9 days after KA. DFMO partially antagonized the convulsant activity and reduced the increased putrescine levels to ∼50% of values in KA-treated animals at 24 h but did not change the pattern of histological damage. The role of polyamines in the early and late phases of KA-induced neurotoxicity is discussed.
Publisher version (URL)http://dx.doi.org/10.1111/j.1471-4159.1991.tb02091.x
http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1991.tb02091.x/abstract
URIhttp://hdl.handle.net/10261/34807
DOI10.1111/j.1471-4159.1991.tb02091.x
ISSN0022-3042
E-ISSN1471-4159
Appears in Collections:(IIBB) Artículos

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