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http://hdl.handle.net/10261/34785
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Romero, Luz | - |
dc.contributor.author | Celada, Pau | - |
dc.contributor.author | Artigas, Francesc | - |
dc.date.accessioned | 2011-04-19T11:06:49Z | - |
dc.date.available | 2011-04-19T11:06:49Z | - |
dc.date.issued | 1994-11-14 | - |
dc.identifier.citation | European Journal of Pharmacology 265 (1-2) : 103-106 (1994) | es_ES |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | http://hdl.handle.net/10261/34785 | - |
dc.description.abstract | 5-HT1A receptor agonists reduce firing-dependent terminal 5-HT synthesis and release by activating somatodendritic 5-HT1A receptors. We have examined the effects of 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT, 0.1 mg/kg s.c.) on in vivo striatal 5-HT release in conscious rats with somatodendritic 5-HT1A receptors inactivated by the application of pertussis toxin in the dorsal raphe nucleus. The uncoupling of 5-HT1A receptors from hyperpolarizing potassium channels was demonstrated by the inability of the intra-raphe application of citalopram to reduce striatal release (control animals had a 47% reduction, an effect prevented by previous treatment with the 5-HT1A antagonist (-)-tertatolol). Yet 8-OH-DPAT (0.1 mg/kg s.c.) decreased striatal 5-HT release by 66% (peak effect) in pertussis toxin-treated rats, a value comparable to that found in naive animals (74%). This raises the possibility that other 8-OH-DPAT-sensitive serotonergic receptors different from 5-HT1A autoreceptors may be involved in the control of terminal 5-HT release. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Dorsal raphe nucleus | es_ES |
dc.subject | G-protein | es_ES |
dc.subject | 5-HT1A receptors | es_ES |
dc.subject | 5-HT (5-hydroxytryptamine, serotonin) release | es_ES |
dc.subject | Microdialysis | es_ES |
dc.subject | Intracerebral | es_ES |
dc.subject | 8 -OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin) | es_ES |
dc.title | Reduction of in vivo striatal 5-HT release by 8-OH-DPAT after inactivation of Gi/o proteins in dorsal raphe nucleus. | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/0014-2999(94)90230-5 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/0014-2999(94)90230-5 | es_ES |
dc.identifier.e-issn | 1879-0712 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
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accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
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