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Title

Reduction of in vivo striatal 5-HT release by 8-OH-DPAT after inactivation of Gi/o proteins in dorsal raphe nucleus.

AuthorsRomero, Luz; Celada, Pau ; Artigas, Francesc
KeywordsDorsal raphe nucleus
G-protein
5-HT1A receptors
5-HT (5-hydroxytryptamine, serotonin) release
Microdialysis
Intracerebral
8 -OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin)
Issue Date14-Nov-1994
PublisherElsevier
CitationEuropean Journal of Pharmacology 265 (1-2) : 103-106 (1994)
Abstract5-HT1A receptor agonists reduce firing-dependent terminal 5-HT synthesis and release by activating somatodendritic 5-HT1A receptors. We have examined the effects of 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT, 0.1 mg/kg s.c.) on in vivo striatal 5-HT release in conscious rats with somatodendritic 5-HT1A receptors inactivated by the application of pertussis toxin in the dorsal raphe nucleus. The uncoupling of 5-HT1A receptors from hyperpolarizing potassium channels was demonstrated by the inability of the intra-raphe application of citalopram to reduce striatal release (control animals had a 47% reduction, an effect prevented by previous treatment with the 5-HT1A antagonist (-)-tertatolol). Yet 8-OH-DPAT (0.1 mg/kg s.c.) decreased striatal 5-HT release by 66% (peak effect) in pertussis toxin-treated rats, a value comparable to that found in naive animals (74%). This raises the possibility that other 8-OH-DPAT-sensitive serotonergic receptors different from 5-HT1A autoreceptors may be involved in the control of terminal 5-HT release.
Publisher version (URL)http://dx.doi.org/10.1016/0014-2999(94)90230-5
URIhttp://hdl.handle.net/10261/34785
DOI10.1016/0014-2999(94)90230-5
ISSN0014-2999
E-ISSN1879-0712
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(CID) Artículos
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