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Title

Acceleration of the effect of selected antidepressant drugs in major depression by 5-HT1A antagonists

AuthorsArtigas, Francesc ; Romero, Luz; Montigny, Claude de; Blier, Pierre
KeywordsAntidepressants
Dorsal raphe nucleus
Hippocampus
Dindolol
Serotonin
5-HT1a antagonists
Issue DateSep-1996
PublisherElsevier
CitationTrends in Neurosciences 19 (9) : 378-383 (1996)
AbstractAt clinically relevant doses, selective serotonin (5-HT) reuptake inhibitors (SSRIs) and MAO inhibitors (MAOIs) increase the extracellular concentration of 5-HT in the midbrain raphé nuclei, thereby activating inhibitory somatodendritic 5-HT1A autoreceptors. Consequently, the firing activity of 5-HT neurons is reduced and the enhancement of extracellular 5-HT concentration in forebrain is dampened. Overriding this feedback by using antagonists of 5-HT1A autoreceptors permits SSRIs to produce a marked increase of extracellular 5-HT in the forebrain. Hence, combined treatment with an SSRI and a 5-HT1A antagonist increases the extracellular concentration of 5-HT more so than the former drug alone. The treatment of patients with major depression using an SSRI and pindolol, a 5-HT1A/β-adrenoceptor antagonist, markedly reduced the latency of the antidepressant response in previously untreated patients and induced a rapid improvement in treatment-resistant patients.
Publisher version (URL)http://dx.doi.org/10.1016/S0166-2236(96)10037-0
URIhttp://hdl.handle.net/10261/34764
DOI10.1016/S0166-2236(96)10037-0
ISSN0166-2236
E-ISSN1878-108X
Appears in Collections:(IIBB) Artículos
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