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Título : Similarities and differences in RANTES and (AOP)-RANTES-triggered signals : implications for chemotaxis
Autor : Rodríguez Frade, José M.; Vila-Coro, Antonio J.; Nieto, Marta; Sánchez Madrid, Francisco; Proudfoot, Amanda; Wells, Timothy N.C.; Martínez-Alonso, Carlos; Mellado, Mario
Palabras clave : Chemokines
Receptor dimerization
Inflammation
HIV-1
Fecha de publicación : feb-1999
Editor: Rockefeller University Press
Citación : The Journal of Cell Biology, 144 (4): 755-765 (1999)
Resumen: Chemokines are a family of proinflammatory cytokines that attract and activate specific types of leukocytes. Chemokines mediate their effects via interaction with seven transmembrane G proteinÐcoupled receptors (GPCR). Using CCR5-transfected HEK-293 cells, we show that both the CCR5 ligand, RANTES, as well as its derivative, aminooxypentane (AOP)-RANTES, trigger immediate responses such as Ca2+ influx, receptor dimerization, tyrosine phosphorylation,and Gai as well as JAK/STAT association to the receptor. In contrast to RANTES, (AOP)-RANTES is unable to trigger late responses, as measured by the association of focal adhesion kinase (FAK) to the chemokine receptor complex, impaired cell polarization required for migration, or chemotaxis. The results are discussed in the context of the dissociation of the late signals, provoked by the chemokines required for cell migration, from early signals.
Descripción : 11 páginas, 8 figuras.
Versión del editor: http://dx.doi.org/10.1083/jcb.144.4.755
URI : http://hdl.handle.net/10261/3476
DOI: 10.1083/jcb.144.4.755
ISSN: 0021-9525
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