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Similarities and differences in RANTES and (AOP)-RANTES-triggered signals : implications for chemotaxis

AutorRodríguez Frade, José M.; Vila-Coro, Antonio J.; Nieto, Marta; Sánchez Madrid, Francisco; Proudfoot, Amanda; Wells, Timothy N.C.; Martínez-Alonso, Carlos; Mellado, Mario
Palabras claveChemokines
Receptor dimerization
Inflammation
HIV-1
Fecha de publicaciónfeb-1999
EditorRockefeller University Press
CitaciónThe Journal of Cell Biology, 144 (4): 755-765 (1999)
ResumenChemokines are a family of proinflammatory cytokines that attract and activate specific types of leukocytes. Chemokines mediate their effects via interaction with seven transmembrane G proteinÐcoupled receptors (GPCR). Using CCR5-transfected HEK-293 cells, we show that both the CCR5 ligand, RANTES, as well as its derivative, aminooxypentane (AOP)-RANTES, trigger immediate responses such as Ca2+ influx, receptor dimerization, tyrosine phosphorylation,and Gai as well as JAK/STAT association to the receptor. In contrast to RANTES, (AOP)-RANTES is unable to trigger late responses, as measured by the association of focal adhesion kinase (FAK) to the chemokine receptor complex, impaired cell polarization required for migration, or chemotaxis. The results are discussed in the context of the dissociation of the late signals, provoked by the chemokines required for cell migration, from early signals.
Descripción11 páginas, 8 figuras.
Versión del editorhttp://dx.doi.org/10.1083/jcb.144.4.755
URIhttp://hdl.handle.net/10261/3476
DOI10.1083/jcb.144.4.755
ISSN0021-9525
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