Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/34718
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | GABAB-R1 receptors in serotonergic neurons: effects of baclofen on 5-HT output in rat brain |
Otros títulos: | GABA(B)-RI receptors in serotonergic neurons: Effects of baclofen on 5-HT output in rat brain | Autor: | Abellán, M. Teresa; Adell, Albert CSIC ORCID ; Honrubia, María Ángeles; Mengod Los Arcos, Guadalupe CSIC ORCID; Artigas, Francesc CSIC ORCID | Fecha de publicación: | 7-abr-2000 | Editor: | Lippincott Williams & Wilkins | Citación: | NeuroReport 11 (5) : 941-945 (2000) | Resumen: | The activation of GABAB receptors hyperpolarizes 5-HT neurons and reduces cell firing. In situ hybridization showed the presence of the GABAB-RI receptor transcript in virtually all 5-HT neurons of the dorsal and median raphe nuclei (DR and MnR, respectively) whereas the GAD transcript was present mainly outside these nuclei. The systemic administration of baclofen increased the in vivo 5-HT release in the DR, MnR and several projection areas. As shown previously in the DR, the application of baclofen in the MnR increased the local 5-HT output. Thus, although 5-HT neurons contain inhibitory GABAB-RI receptors, baclofen increased 5-HT release in some brain areas, likely by a preferential action on terminal GABAB autoreceptors in inhibitory inputs to 5-HT neurons. The scarcity of GAD-expressing cells in the DR and MnR suggests that these inputs originate mainly outside these nuclei. | Versión del editor: | http://journals.lww.com/neuroreport/Abstract/2000/04070/GABAB_RI_receptors_in_serotonergic_neurons_.9.aspx | URI: | http://hdl.handle.net/10261/34718 | ISSN: | 0959-4965 | E-ISSN: | 1473-558X |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
Page view(s)
324
checked on 23-abr-2024
Download(s)
42
checked on 23-abr-2024
Google ScholarTM
Check
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.