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| Título: | 5-HT(2A) receptor binding is reduced in drug-naive and unchanged in SSRI-responder depressed patients compared to healthy controls: a PET study |
Autor: | Messa, Cristina; Artigas, Francesc CSIC ORCID | Palabras clave: | Major depression Serotonin receptors Emission tomography Antidepressant |
Fecha de publicación: | 11-mar-2003 | Editor: | Springer Nature | Citación: | Psychopharmacology 167(1): 72-78 (2003) | Resumen: | [Objective]: The aim of the study was to
investigate differences in 5-HT2A receptor binding between healthy volunteers and patients with major depressive disorder (MDD), either never treated before with
antidepressants (drug-naive: DN) or responding to paroxetine treatment (drug-treated: DT) [Methods]: Nineteen DN patients with MDD and 15 euthymic DT (paroxetine 4 weeks) patients were compared with a group of 20 healthy controls (C) with positron emission tomography (PET) using [(18)F]fluoroethylspiperone ([(18)F]FESP), a 5-HT(2A) and D(2) receptor antagonist. A "binding index" (BI) of [(18)F]FESP to cortical and basal ganglia regions was calculated as the ratio of the activity in these regions to that of cerebellum. Differences in BI between groups, i.e. C versus DN or DT, were assessed by ANOVA, with or without age as covariate (ANCOVA). [Results]: A significant reduction in BI ( P=0.003 ANOVA, P=0.001 ANCOVA) was found in DN patients in the frontal, occipital, temporal and cingulate cortices, but not in the striatum. No significant differences emerged between C and DT patients. [Conclusions]: The reduction of [(18)F]FESP BI in cortical areas of DN depressed, but not of euthymic DT patients suggests an association between the occurrence of depressive symptoms and impairment of cortical 5-HT(2A) receptors. [(18)F]FESP cortical BI may represent a state marker of depression. |
Descripción: | Cristina Messa et al. | Versión del editor: | http://dx.doi.org/10.1007/s00213-002-1379-5 | URI: | http://hdl.handle.net/10261/34695 | DOI: | 10.1007/s00213-002-1379-5 | ISSN: | 0033-3158 | E-ISSN: | 1432-2072 |
| Aparece en las colecciones: | (IIBB) Artículos |
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