English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/3467
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Role of Akt and c-Jun N-terminal Kinase 2 in Apoptosis Induced by Interleukin-4 Deprivation

AutorCerezo, Ana; Martínez-Alonso, Carlos; Lanzarot, Diego; Fischer, Siegmund; Franke, Thomas F.; Rebollo, Angelita
Fecha de publicaciónnov-1998
EditorAmerican Society for Cell Biology
CitaciónMolecular Biology of the Cell, Vol. 8, pp. 3107–3118, November 1998
ResumenWe have shown previously that interleukin-4 (IL-4) protects TS1ab cells from apoptosis, but very little is known about the mechanism by which IL-4 exerts this effect. We found that Akt activity, which is dependent on phosphatidylinositol 3 kinase, is reduced in IL-4-deprived TS1ab cells. Overexpression of wild-type Akt or a constitutively active Akt mutant protects cells from IL-4 deprivation-induced apoptosis. Readdition of IL-4 before the commitment point is able to restore Akt activity. We also show expression and c-Jun N-terminal kinase 2 activation after IL-4 deprivation. Overexpression of the constitutively activated Akt mutant in IL-4-deprived cells correlates with inhibition of c-Jun N-terminal kinase 2 activity. Finally, TS1ab survival is independent of Bcl-2, Bcl-x, or Bax.
DescripciónEl copyright pertenece a The American Society for Cell Biology. The final versión of the paper is available at http://www.pubmedcentral.nih.gov
URIhttp://hdl.handle.net/10261/3467
ISSN1059-1524
Aparece en las colecciones: (CNB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
250.pdf351,61 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.