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Title

Strategies for producing faster acting antidepressants

AuthorsAdell, Albert ; Castro, Elena ; Celada, Pau ; Bortolozzi, Analía ; Pazos, Ángel ; Artigas, Francesc
KeywordsDepression
Antidepressant
5-HT receptors
Serotonin
NK1 receptors
Corticotrophin-releasing facto
Glutamate
cAMP
Issue Date15-Apr-2005
PublisherElsevier
CitationDrug Discovery Today 10 (8) : 578-585 (2005)
AbstractExisting antidepressant treatments exhibit limited efficacy and a slow onset of action. Several neurobiological adaptive mechanisms might delay the clinical effects of antidepressants, whose therapeutic action is primarily triggered by an increase of serotonergic and noradrenergic neurotransmission. Here, we review several potential mechanisms that could be useful to increase the speed of current antidepressant drugs, such as additional blockade of aminergic autoreceptors or antagonism of certain postsynaptic (5-HT2A, 5-HT2C) receptors. The potential use of strategies not based on monoaminergic transmission, such as CRF and NK1 receptor antagonists, or more novel strategies, based on glutamatergic or GABAergic transmission or on intracellular messengers, are also reviewed. The global impact of depression is growing but there have been no substantial advances to overcome two main problems of its treatment: slowness and limited efficacy. This review focuses on potential neurobiological mechanisms to produce rapidly acting antidepressants.
Publisher version (URL)http://dx.doi.org/10.1016/S1359-6446(05)03398-2
URIhttp://hdl.handle.net/10261/34590
DOI10.1016/S1359-6446(05)03398-2
ISSN1359-6446
E-ISSN1878-5832
Appears in Collections:(IIBB) Artículos
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