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Título : Transplanted long-term cultured pre-BI cells expressing calpastatin are resistant to B cell receptor–induced apoptosis
Autor : Ruíz Vela, Antonio; Serrano Gómez, Fernando; González de la Peña, Manuel Angel; Abad, José Luis; Bernad, Antonio; Maki, Masatoshi; Martínez-Alonso, Carlos
Palabras clave : pre-B cells
Calpastatin
Calpain
BCR
Transplant
Fecha de publicación : ago-2001
Editor: Rockefeller University Press
Citación : The Journal of Experimental Medicine, volume 194, number 3, august 6, 2001, pp. 247–254
Resumen: Long-term cultured pre-B cells are able to differentiate into immunoglobulin (Ig)M-positive B cells (IgM cells) when transplanted into severe combined immunodeficient (SCID) mice. Based on previous studies, here we report the development of a reconstitution assay in nonobese diabetic/SCID (NOD/SCID) mice using pre-B cells, which allows us to study the role of calpains (calcium-activated endopeptidases) during B cell development as well as in B cell clonal deletion. Using this model, we show that calpastatin (the natural inhibitor of calpains) inhibits B cell receptor–induced apoptosis in IgM cells derived from transplanted mice. We thus hypothesize an important function for calpain in sculpting the B cell repertoire.
Descripción : Copyright © by The Rockefeller University Press
URI : http://hdl.handle.net/10261/3420
ISSN: 0022-1007
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