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Antiviral activity of lauryl gallate against animal viruses

AuthorsHurtado, Carolina ; Bustos, Maria José; Sabina, Prado ; Nogal París, María Luisa ; Granja, Aitor G. ; González, María Eugenia; González Porque, Pedro; Revilla Novella, Yolanda ; Carrascosa, Ángel L.
KeywordsLauryl gallate
Antiviral therapy
Issue Date2008
PublisherMedical Press
CitationAntiviral Therapy 13(7): 909-17 (2008)
AbstractThe effect of the anti-tumoral drug lauryl gallate on the infectivity of the African swine fever virus among other DNA (Herpes simplex and Vaccinia) and RNA (Influenza, Porcine transmissible gastroenteritis and Sindbis) viruses, involved in animal and human diseases, is analyzed. Viral production was strongly inhibited in different cell lines at non-toxic concentrations of the drug (1-10 μM), reducing the titres from 3 to more than 5 log. units depending on the multiplicity of infection. In our model system (African swine fever virus in Vero cells), the addition of the drug 1 h before virus adsorption, completely abolished virus productivity in a one-step growth virus cycle. Interestingly, no inhibitory effect was observed when lauryl gallate was added after 5 to 8 hpi. Both cellular and viral DNA synthesis and late viral transcription were inhibited by the drug, but, however, the early viral protein synthesis and the virus-mediated increasing of p53 remained unaffected. Activation of the apoptotic effector caspase-3 was not detected after lauryl gallate treatment of Vero cells, and, furthermore, the presence of the drug abrogated the activation of this protease induced by the virus infection. The overall results likely indicate that a cellular factor/function might be the target of the antiviral action of alkyl gallates
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