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Title: | New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity |
Authors: | Alonso De Diego, Sergio A.; Gutiérrez-Rodríguez, Marta ![]() ![]() ![]() ![]() ![]() ![]() |
Keywords: | GPE analogues Solid-phase synthesis Neuroprotective activity |
Issue Date: | 2006 |
Publisher: | Elsevier |
Citation: | Bioorganic & Medicinal Chemistry Letters 16 : 1392–1396 (2006) |
Abstract: | A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity. |
Publisher version (URL): | http://dx.doi.org/10.1016/j.bmcl.2005.11.040 |
URI: | http://hdl.handle.net/10261/33944 |
DOI: | doi:10.1016/j.bmcl.2005.11.040 |
Appears in Collections: | (CENQUIOR) Artículos |
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