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New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity

AuthorsAlonso De Diego, Sergio A.; Gutiérrez-Rodríguez, Marta CSIC ORCID ; Pérez de Vega, M. Jesús; Casabona, Diego; Cativiela, Carlos CSIC ORCID; González-Muñiz, Rosario CSIC ORCID; Herranz, Rosario CSIC ORCID; Cenarruzabeitia, Edurne; Frechilla, Diana; Río, Joaquín del; Jimeno, M. Luisa CSIC ORCID; García-López, M. Teresa CSIC
KeywordsGPE analogues
Solid-phase synthesis
Neuroprotective activity
Issue Date2006
CitationBioorganic & Medicinal Chemistry Letters 16 : 1392–1396 (2006)
AbstractA suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
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