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| Title: | New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity |
Authors: | Alonso De Diego, Sergio A.; Gutiérrez-Rodríguez, Marta CSIC ORCID ; Pérez de Vega, M. Jesús; Casabona, Diego; Cativiela, Carlos CSIC ORCID; González-Muñiz, Rosario CSIC ORCID; Herranz, Rosario CSIC ORCID; Cenarruzabeitia, Edurne; Frechilla, Diana; Río, Joaquín del; Jimeno, M. Luisa CSIC ORCID; García-López, M. Teresa CSIC | Keywords: | GPE analogues Solid-phase synthesis Neuroprotective activity |
Issue Date: | 2006 | Publisher: | Elsevier | Citation: | Bioorganic & Medicinal Chemistry Letters 16 : 1392–1396 (2006) | Abstract: | A suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity. | Publisher version (URL): | http://dx.doi.org/10.1016/j.bmcl.2005.11.040 | URI: | http://hdl.handle.net/10261/33944 | DOI: | 10.1016/j.bmcl.2005.11.040 |
| Appears in Collections: | (CENQUIOR) Artículos |
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