English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/33944
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity

AuthorsAlonso De Diego, Sergio A.; Gutiérrez-Rodríguez, Marta ; Pérez de Vega, M. Jesús; Casabona, Diego; Cativiela, Carlos ; González-Muñiz, Rosario ; Herranz, Rosario ; Cenarruzabeitia, Edurne; Frechilla, Diana; Río, Joaquín del; Jimeno, M. Luisa ; García-López, M. Teresa
KeywordsGPE analogues
Solid-phase synthesis
Neuroprotective activity
Issue Date2006
PublisherElsevier
CitationBioorganic & Medicinal Chemistry Letters 16 : 1392–1396 (2006)
AbstractA suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2005.11.040
URIhttp://hdl.handle.net/10261/33944
DOIdoi:10.1016/j.bmcl.2005.11.040
Appears in Collections:(CENQUIOR) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.