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New Gly-Pro-Glu (GPE) analogues: Expedite solid-phase synthesis and biological activity

AuthorsAlonso De Diego, Sergio A.; Gutiérrez-Rodríguez, Marta ; Pérez de Vega, M. Jesús; Casabona, Diego; Cativiela, Carlos ; González-Muñiz, Rosario ; Herranz, Rosario ; Cenarruzabeitia, Edurne; Frechilla, Diana; Río, Joaquín del; Jimeno, M. Luisa ; García-López, M. Teresa
KeywordsGPE analogues
Solid-phase synthesis
Neuroprotective activity
Issue Date2006
CitationBioorganic & Medicinal Chemistry Letters 16 : 1392–1396 (2006)
AbstractA suitable solid-phase approach, based on Fmoc/tBu methodology and on the use of 2-chlorotrityl resin, allowed a rapid and efficient preparation of new GPE analogues. Most of the synthesized tripeptides displayed glutamate receptor binding affinity comparable to that of GPE, but only a few derivatives showed significant neuroprotective activity.
Publisher version (URL)http://dx.doi.org/10.1016/j.bmcl.2005.11.040
Appears in Collections:(CENQUIOR) Artículos
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