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Título : Role of the PI3K regulatory subunit in the control of actin organization and cell migration
Autor : Jiménez, Concepción; Armas Portela, Rosario; Mellado, Mario; Rodríguez Frade, José M.; Collard, John; Serrano, Antonio; Martínez-Alonso, Carlos; Ávila, Jesús; Carrera, Ana C.
Palabras clave : N-WASP
Cdc42
PDGF
Phosphatidylinositol 3-kinase
Actin cytoskeleton
Fecha de publicación : oct-2000
Editor: Rockefeller University Press
Citación : The Journal of Cell Biology, volume 151, number 2, october 16, 2000, pp. 249–261
Resumen: Cell migration represents an important cellular response that utilizes cytoskeletal reorganization as its driving force. Here, we describe a new signaling cascade linking PDGF receptor stimulation to actin rearrangements and cell migration. We demonstrate that PDGF activates Cdc42 and its downstream effector N-WASP to mediate filopodia formation, actin stress fiber disassembly, and a reduction in focal adhesion complexes. Induction of the Cdc42 pathway is independent of phosphoinositide 3-kinase (PI3K) enzymatic activity, but it is dependent on the p85 a regulatory subunit of PI3K. Finally, data are provided showing that activation of this pathway is required for PDGF-induced cell migration on collagen. These observations show the essential role of the PI3K regulatory subunit p85 a in controlling PDGF receptor–induced cytoskeletal changes and cell migration, illustrating a novel signaling pathway that links receptor stimulation at the cell membrane with actin dynamics
Descripción : Copyright © by The Rockefeller University Press
URI : http://hdl.handle.net/10261/3386
ISSN: 0021-9525
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