English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/3386
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Role of the PI3K regulatory subunit in the control of actin organization and cell migration

AuthorsJiménez, Concepción; Armas Portela, Rosario; Mellado, Mario; Rodríguez Frade, José M.; Collard, John; Serrano, Antonio; Martínez-Alonso, Carlos; Ávila, Jesús ; Carrera, Ana C.
KeywordsN-WASP
Cdc42
PDGF
Phosphatidylinositol 3-kinase
Actin cytoskeleton
Issue DateOct-2000
PublisherRockefeller University Press
CitationThe Journal of Cell Biology, volume 151, number 2, october 16, 2000, pp. 249–261
AbstractCell migration represents an important cellular response that utilizes cytoskeletal reorganization as its driving force. Here, we describe a new signaling cascade linking PDGF receptor stimulation to actin rearrangements and cell migration. We demonstrate that PDGF activates Cdc42 and its downstream effector N-WASP to mediate filopodia formation, actin stress fiber disassembly, and a reduction in focal adhesion complexes. Induction of the Cdc42 pathway is independent of phosphoinositide 3-kinase (PI3K) enzymatic activity, but it is dependent on the p85 a regulatory subunit of PI3K. Finally, data are provided showing that activation of this pathway is required for PDGF-induced cell migration on collagen. These observations show the essential role of the PI3K regulatory subunit p85 a in controlling PDGF receptor–induced cytoskeletal changes and cell migration, illustrating a novel signaling pathway that links receptor stimulation at the cell membrane with actin dynamics
DescriptionCopyright © by The Rockefeller University Press
URIhttp://hdl.handle.net/10261/3386
ISSN0021-9525
Appears in Collections:(CNB) Artículos
Files in This Item:
File Description SizeFormat 
309.pdf785,35 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.