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dc.contributor.authorDíaz-Moreno, Irene-
dc.contributor.authorHollingworth, David-
dc.contributor.authorKelly, Geoff-
dc.contributor.authorMartin, Stephen-
dc.contributor.authorGarcía-Mayoral, M.F.-
dc.contributor.authorBriata, Paola-
dc.contributor.authorGherzi, Roberto-
dc.contributor.authorRamos, Andrés-
dc.date.accessioned2011-03-25T17:16:29Z-
dc.date.available2011-03-25T17:16:29Z-
dc.date.issued2010-04-12-
dc.identifier.citationNucleic Acids Research 38(15): 5193-5205 (2010)es_ES
dc.identifier.issn0305-1049-
dc.identifier.urihttp://hdl.handle.net/10261/33804-
dc.description13 páginas, 8 figuras, 1 tablaes_ES
dc.description.abstractKSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3′UTR, that is mediated by KSRP’s KH domains. Our structural analysis shows that the inter-domain linker orients the two central KH domains of KSRP—and their RNA-binding surfaces—creating a two-domain unit. We also show that this inter-domain arrangement is important to the interaction with KSRP’s RNA targets.es_ES
dc.description.sponsorshipWellcome Trust Grant WT082088MA and the MRC Grant-in-Aid U117574558. I.D.M. was supported by European Molecular Biology Organization (EMBO), fellowship number 240-2005. The work of P.B. and R.G. has been partly supported by grants from Italian ISS (526D/39) to P.B., ISS (527B/2B/6), Associazione Italiana per la Ricerca sul Cancro (AIRC), and CIPE 2007 (Regione Liguria) to R.G. Funding for open access charge: MRC grant-in-aid (U117574558).es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.rightsopenAccesses_ES
dc.subjectKSRPes_ES
dc.subjectRNAes_ES
dc.subjectInflammatoryes_ES
dc.subjectCellular proliferationes_ES
dc.subjectKHes_ES
dc.titleOrientation of the central domains of KSRP and its implications for the interaction with the RNA targetses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1093/nar/gkq216-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1093/nar/gkq216es_ES
dc.identifier.e-issn1362-4962-
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