English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/33804
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Orientation of the central domains of KSRP and its implications for the interaction with the RNA targets

AuthorsDíaz-Moreno, Irene ; Hollingworth, David; Kelly, Geoff; Martin, Stephen; García-Mayoral, M.F. ; Briata, Paola; Gherzi, Roberto; Ramos, Andrés
KeywordsKSRP
RNA
Inflammatory
Cellular proliferation
KH
Issue Date12-Apr-2010
PublisherOxford University Press
CitationNucleic Acids Research 38(15): 5193-5205 (2010)
AbstractKSRP is a multi-domain RNA-binding protein that recruits the exosome-containing mRNA degradation complex to mRNAs coding for cellular proliferation and inflammatory response factors. The selectivity of this mRNA degradation mechanism relies on KSRP recognition of AU-rich elements in the mRNA 3′UTR, that is mediated by KSRP’s KH domains. Our structural analysis shows that the inter-domain linker orients the two central KH domains of KSRP—and their RNA-binding surfaces—creating a two-domain unit. We also show that this inter-domain arrangement is important to the interaction with KSRP’s RNA targets.
Description13 páginas, 8 figuras, 1 tabla
Publisher version (URL)http://dx.doi.org/10.1093/nar/gkq216
URIhttp://hdl.handle.net/10261/33804
DOI10.1093/nar/gkq216
ISSN0305-1049
E-ISSN1362-4962
Appears in Collections:(IBVF) Artículos
Files in This Item:
File Description SizeFormat 
NAR_2010_38_5193.pdf1,92 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.