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Title

Simple approach to highly functionalized trisubstituted tetrahydropyrimidine-2,4-diones from perhydropyrazino[1,2-f]pyrimidine-3,6,8- trione precursors

AuthorsPatiño-Molina, Rosario; García-López, M. Teresa CSIC ; Cenarruzabeitia, Edurne CSIC; Río, Joaquín del CSIC; González-Muñiz, Rosario CSIC ORCID
KeywordsHeterocycles
Peptides
Bicyclic compounds
Ring opening
Medicinal chemistry
Issue Date2007
PublisherGeorg Thieme Verlag
CitationSynthesis 7: 1047-1053 (2007)
AbstractUnprecedented trisubstituted tetrahydropyrimidine-2,4-diones were easily synthesized in two steps involving Boc-amide protection and controlled ring opening, from perhydropyrazino[1,2-f]pyrimidine-3,6,8-triones. These bicyclic derivatives were prepared by reaction of 2-oxopiperazines derived from dipeptides with isocyanates, followed by cyclization. The monocyclic pyrimidinone derivatives were further elaborated to potential CCK ligands that have contributed to a better understanding of the structural requirements for efficient binding at the CCK1 receptor.
Publisher version (URL)http://dx.doi.org/10.1055/s-2007-965962
URIhttp://hdl.handle.net/10261/336379
DOI10.1055/s-2007-965962
ISSN0039-7881
E-ISSN1437-210X
Appears in Collections:(IQM) Artículos




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