English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/33508
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Apoptosis induced by parasitic diseases

AuthorsBienvenu, Anne-Lise; González-Rey, Elena; Picot, Stephane
Issue Date17-Nov-2010
PublisherBioMed Central
CitationParasites & Vectors 3: 106 (2010)
SeriesProtozoan parasites and cell death
AbstractFatalities caused by parasitic infections often occur as a result of tissue injury that results from a form of host-cell death known as apoptosis. However, instead of being pathogenic, parasite-induced apoptosis may facilitate host survival. Consequently, it is of utmost importance to decipher and understand the process and the role of apoptosis induced or controlled by parasites in humans. Despite this, few studies provide definitive knowledge of parasite-induced host-cell apoptosis. Here, the focus is on a consideration of host-cell apoptosis as either a pathogenic feature or as a factor enabling parasite survival and development. Cell death by apoptotic-like mechanisms could be described as a ride to death with a return ticket, as initiation of the pathway may be reversed, with the potential that it could be manipulated for therapeutic purposes. The management of host-cell apoptosis could thus be an adjunctive factor for parasitic disease treatment. Evidence that the apoptotic process could be reversed by anti-apoptotic drugs has recently been obtained, leading to the possibility of host-cell rescue after injury. An important issue will be to predict the beneficial or deleterious effects of controlling human cell death by apoptotic-like mechanisms during parasitic diseases.
Description9 páginas.-- Edited by Hilary Hurd.
Publisher version (URL)http://dx.doi.org/10.1186/1756-3305-3-106
Appears in Collections:(IPBLN) Artículos
Files in This Item:
File Description SizeFormat 
1756-3305-3-106.pdf289,26 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.