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Título: | Biological consequences of oxygen desaturation and respiratory effort in an acute animal model of obstructive sleep apnea (OSA) |
Autor: | Nácher, María CSIC; Farré, Ramón; Montserrat, Josep M. CSIC ORCID; Torres, Marta; Navajas, Daniel; Bulbena, Oriol CSIC; Serrano-Mollar, Anna CSIC ORCID | Palabras clave: | Obstructive apnea Inflammation Endothelial dysfunction Respiratory effort Hypoxia Animal models |
Fecha de publicación: | 8-sep-2009 | Editor: | Elsevier | Citación: | Sleep Medicine 10(8): 892-897 (2009) | Resumen: | [Background]: An animal model mimicking all the factors involved in obstructive sleep apnea (OSA) is useful for investigating mechanisms because the associated comorbidity usually present in such patients is an important limitation. [Aim]: To test the hypothesis that hypoxia/normoxia and respiratory effort have different effects on the induction of inflammatory response and endothelial dysfunction in an acute rat model of OSA. [Methods]: Four groups of anesthetized rats were studied (n = 8): (1) sham; (2) apnea: obstructions (15 s each, 60/h, for 3 h); (3) apnea + O2: obstructions and breathing oxygen-enriched air to avoid hypoxia and (4) intermittent hypoxia/normoxia. Inflammatory and endothelial mediators were measured as outcomes along with NF-κB in the lung and diaphragm. [Results]: TNF-α and IL-1β significantly increased in all groups compared with sham. NF-κB in the lung was increased in apnea and hypoxia/normoxia groups, but not in apnea + O2 group. In diaphragm tissue, NF-κB was only significant in apnea compared to sham. Significant differences were found in the ratio thromboxane-B2/6-keto-Prostaglandin-F1α between apnea and hypoxia/normoxia compared to sham but not in apnea + O2. [Conclusions]: Oxygen desaturations and respiratory efforts play a role in the induction of systemic inflammation but only hypoxia/normoxia induces endothelial dysfunction. These data suggest a potential role for oxygen therapy in patients with OSA. |
Descripción: | El pdf del artículo es el manuscrito de autor. | Versión del editor: | http://dx.doi.org/10.1016/j.sleep.2008.09.014 | URI: | http://hdl.handle.net/10261/33423 | DOI: | 10.1016/j.sleep.2008.09.014 | ISSN: | 1389-9457 | E-ISSN: | 1878-5506 |
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Biological consequences of oxygen.pdf | 235,11 kB | Adobe PDF | Visualizar/Abrir |
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