Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/33213
Share/Export:
logo share SHARE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

3-oxopiperazinium derivatives as agonists of nerve growth factor receptors and their use as medicaments

AuthorsMoreno, Beatriz; Villoslada, Pablo; Messeguer, Joaquim; Navarro, Gloria; Messeguer Peypoch, Ángel CSIC ORCID
KeywordsNerve growth factor
Issue Date3-Mar-2011
CitationWO2011024078 A1
AbstractNew 3-oxopiperazinium derivatives agonists of Nerve Growth Factor receptors and their use as medicaments. Neurotrophin binding to its specific receptor Trk A leads to the activation of multiple signalling cascades, culminating in neuroregenerative effects, including neuronal survival and neurite outgrowth. Neurotrophic factors have been used for the treatment of several neurodegenerative diseases. However, their use is limited by their inability to cross the blood-brain barrier, their short half life and their side effects. Small molecule neurotrophin peptidomimetics may be beneficial in treating a number of neurodegenerative disorders. The present invention shows the capacity of nerve growth factor agonist molecules derived from the 3- oxopiperazinium scaffold to induce differentiation in PC12 cells and, therefore, that these small molecules with NGF agonist activity may be beneficial for treatment of neurodegenerative diseases, due to their neuroregenerative effects.
URIhttp://hdl.handle.net/10261/33213
Appears in Collections:(IQAC) Patentes

Files in This Item:
File Description SizeFormat
WO2011024078A1.pdf3,06 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

Page view(s)

286
checked on May 18, 2022

Download(s)

103
checked on May 18, 2022

Google ScholarTM

Check


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.