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CD209 in inflammatory bowel disease: a case-control study in the Spanish population
|Authors:||Núñez, Concepción; Oliver, Francisco Javier; Mendoza, Juan L.; Gómez-García, M.; Taxonera, Carlos; Gómez, Luis M.; López-Nevot, Miguel-Ángel; Concha, Emilio G. de la; Urcelay, Elena; Martínez, Alfonso; Martín, J.|
|Citation:||BMC Medical Genetics 2007, 8:75|
|Abstract:||[Background] The etiology of Ulcerative Colitis (UC) and Crohn's Disease (CD), considered
together as Inflammatory Bowel Diseases (IBD), involves environmental and genetic factors.
Although some genes are already known, the genetics underlying these diseases is complex and
new candidates are continuously emerging. The CD209 gene is located in a region linked previously
to IBD and a CD209 functional polymorphism (rs4804803) has been associated to other
inflammatory conditions. Our aim was to study the potential involvement of this CD209 variant in
[Methods] We performed a case-control study with 515 CD patients, 497 UC patients and 731 healthy controls, all of them white Spaniards. Samples were typed for the CD209 single nucleotide polymorphism (SNP) rs4804803 by TaqMan technology. Frequency comparisons were performed using χ2 tests.
[Results] No association between CD209 and UC or CD was observed initially. However, stratification of UC patients by HLA-DR3 status, a strong protective allele, showed that carriage of the CD209_G allele could increase susceptibility in the subgroup of HLA-DR3-positive individuals (p = 0.03 OR = 1.77 95% CI 1.04–3.02, vs. controls).
[Conclusion] A functional variant in the CD209 gene, rs4804803, does not seem to be influencing Crohn's disease susceptibility. However, it could be involved in the etiology or pathology of Ulcerative Colitis in HLA-DR3-positive individuals but further studies are necessary.
|Description:||This article is available from: http://www.biomedcentral.com/1471-2350/8/75|
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